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Malegra 200mg - A PDE-5 Inhibitor

  • Malegra 200mg is a popular drug that is used to treat erectile dysfunction. This medication is a PDE-5 inhibitor and helps men to get a firm erection.

    It works by relaxing the muscles and increasing blood flow in the penile veins. This increases the amount of blood that flows to the penis, causing it to become hard and erect.

    Sildenafil Citrate

    Sildenafil Malegra citrate is a phosphodiesterase 5 inhibitor (PDE-5 inhibitor) that has been used to treat erectile dysfunction in men and to control pulmonary arterial hypertension in both men and women. Generic sildenafil is available and may be cheaper than brand-name medications.

    The Malegra 100 medication is an oral tablet that works by inhibiting cGMP-specific type 5 phosphodiesterase and resulting in vasodilation of the corpus cavernosum. This increases blood flow to the penis and helps a man get and keep an erection.

    Malegra 25mg is taken orally as a single dose, usually 30 minutes to 4 hours before sexual activity. Do not take more than one dose a day, as this may increase side effects.

    During treatment, your doctor will check your response to the drug. You may need to increase your dosage or stop taking it if you do not get the results you want.

    You should tell your doctor if you have low blood pressure, an irregular heartbeat, or a history of stroke or other heart problems. Also, you should not take this medication if you have had stomach bleeding, ulcers, or small holes in your digestive tract.

    Phosphodiesterase 5 Inhibitor

    Phosphodiesterase 5 Inhibitor is a type of medication that's commonly used to treat erectile dysfunction (ED). It works by blocking the action of an enzyme called phosphodiesterase 5.

    This enzyme breaks down a cyclic nucleotide called cGMP. This helps relax smooth muscle cells and increase blood flow to certain tissues, including the erectile tissue of the penis.

    The PDE5 enzyme is found in the lungs and the corpus cavernosum (a part of the penis). Inhibitors of this enzyme increase blood flow to these parts of the body, making it easier for you to get and maintain an erection.

    PDE5 inhibitors also act on the heart, improving heart function in patients with heart failure and myocardial infarction. Some studies suggest they can regress left ventricular hypertrophy, improve myocardial contractility and reduce ischemia-induced ventricular arrhythmias.

    Cyclic Guanosine Monophosphate

    Cyclic guanosine monophosphate, or cGMP, is a secondary messenger that modulates a number of different cellular responses including visual transduction, calcium homeostasis, and neurotransmission. It is produced in cells through the stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase.

    Nitric oxide is synthesized in endothelial cells in the tunica media of blood vessels and then diffuses to smooth muscle in the vessel walls, where it activates an enzyme called guanylyl cyclase to convert nitric oxide into cyclic guanosine monophosphate. This second messenger induces the relaxation of smooth muscle cells in the vessel wall, which leads to vasodilation.

    Drugs that promote vasodilation by potentiating cGMP are used to treat hypertension and angina pectoris. These drugs include hydralazine, nitroprusside, and nitrates. The cGMP/phosphodiesterase 5 pathway is also important in the regulation of vascular smooth muscle cell function, including proliferation, apoptosis, and cell adhesion.


    Malegra 200mg is a powerful medication to treat erectile dysfunction. It contains the active ingredient Sildenafil Citrate USP.

    This medicine works by inhibiting the phosphodiesterase 5 enzyme in the body. This prevents the degradation of cGMP, which helps relax the veins in the penis and boosts blood flow.

    The dosage of this drug should be used as prescribed by your doctor. Do not take more than one pill per day.

    If you experience any side effects when taking this medicine, consult your doctor right away. Symptoms can include dizziness, drowsiness, headache, and blurred vision.

    In addition, it may affect your ability to drive or perform other tasks. It also affects your heart rate and blood pressure. You should avoid eating grapefruit or drinking grape juice while taking this medicine. This can have a negative effect on the medication's efficacy.

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